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为探索烧伤早期血清急性期蛋白的变化规律及其临床意义,将32例烧伤病人按烧伤总面积大小分为小于20%,20%～50%和大于50%三组。于伤后8,24,48,72小时采血,组3加测伤后7,14,21天三个时相点以观察与感染的关系。以免疫速率散射浊度法测定 CRP,C_3,T_1用琼脂扩散法,PA 用火箭免疫电冰法测定。结果表明:伤后48～72小时血清 CRP 达到高峰(P<0.01);伤后8小时 C_3显著下降(P<0.05),24小时达最低值,C_3下降与 CRP 升高无相关性(r=0.0885,P>0.05);48小时 T_f 显著下降(P<0.01),PA 与 T_f 变化相似。感染及脓毒症发生时各监测指标变化不显著。提示:①CRP 的变化主要反映组织损伤的程度而不能预示脓毒症的易感性;②C_3下降并非 CRP 升高引起。T_f 下降有利于细菌生长。
In order to explore the changing rules and clinical significance of serum acute phase protein in early stage of burn, 32 cases of burn patients were divided into three groups of less than 20%, 20% -50% and more than 50% according to the total burn area. At 8, 24, 48, and 72 hours after injury, blood was collected. Group 3 plus three time points after 7, 14, and 21 days of trauma to observe the relationship with infection. The CRP, C_3 and T_1 were determined by the immunostaining scattering nephelometry using the agar diffusion method, and the PA was determined by rocket immunoelectrophoresis. The results showed that serum CRP peaked at 48 to 72 hours after injury (P <0.01), decreased significantly at 8 hours post injury (P <0.05), reached the lowest at 24 hours, and decreased with C_3. 0.0885, P> 0.05). The T_f decreased significantly at 48 hours (P <0.01). The changes of PA and T_f were similar. Infection and sepsis when the monitoring indicators did not change significantly. Tip: ① CRP changes mainly reflect the degree of tissue damage can not predict the susceptibility to sepsis; ② C_3 decline is not caused by elevated CRP. T_f decline is conducive to bacterial growth.