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Survivin是近年发现的结构独特的凋亡抑制蛋白家族成员,具有抑制细胞凋亡、调节细胞有丝分裂的双重功能。Survivin具有肿瘤特异性,在正常成人组织中少见表达却高表达于多种肿瘤组织且与肿瘤细胞的浸润和病人的不良预后密切相关。本文对Survivin的生物学功能及其与口腔颌面部上皮性肿瘤关系的研究进展进行综述。
Survivin is a unique member of the apoptosis-inhibiting protein family found in recent years. It has the dual functions of inhibiting apoptosis and regulating cell mitosis. Survivin is tumor-specific and rarely expressed in normal adult tissues but highly expressed in many tumor tissues and is closely related to tumor cell infiltration and poor patient prognosis. This review summarizes the biological functions of Survivin and its relationship with oral and maxillofacial malignant tumors.