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Background:Male sex workers are at high-risk for acquisition of sexually transmitted infections(STIs),including human immunodeficiency virus(HIV).We quantified incidence rates of STIs and identified their time-varying predic-tors among male sex workers in Mexico City.Methods:From January 2012 to May 2014,male sex workers recruited from the largest HIV clinic and community sites in Mexico City were tested for chlamydia,gonorrhea,syphilis,hepatitis,and HIV at baseline,6-months,and 12-months.Incidence rates with 95％bootstrapped confidence limits were calculated.We examined potential time-varying predictors using generalized estimating equations for a population averaged model.Results:Among 227 male sex workers,median age was 24 and baseline HIV prevalence was 32％.Incidence rates(per 100 person-years)were as follows:HIV[5.23;95％confidence interval(CI):2.15-10.31],chlamydia(5.15;95％Cl:2.58-9.34),gonorrhea(3.93;95％CI:1.88-7.83),syphilis(13.04;95％CI:8.24-19.94),hepatitis B(2.11;95％CI:0.53-4.89),hepatitis C(0.95;95％CI:0.00-3.16),any STI except HIV(30.99;95％CI:21.73-40.26),and any STI including HIV(50.08;95％CI:37.60-62.55).In the multivariable-adjusted model,incident STI(excluding HIV)were lower among those who reported consistently using condoms during anal and vaginal intercourse(odds ratio=0.03,95％CI:0.00-0.68)com-pared to those who reported inconsistently using condoms during anal and vaginal intercourse.Conclusions:Incidence of STIs is high among male sex workers in Mexico City.Consistent condom use is an impor-tant protective factor for STIs,and should be an important component of interventions to prevent incident infections.