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目的 探讨子宫内膜异位症病人体内免疫学改变。方法 对１８例正常生育期的妇女及３４例各期内膜异位症的患者分别检测其血清及腹腔液中抗子宫内膜抗体、ＩＬ４、ＩＦＮγ的水平。结果 血清中内异症组与对照组比较抗子宫内膜抗体阳性率有显著性差异（Ｐ＜０．００５）；ＩＬ４水平在腹腔液中内异症各期与对照组比较及内异症Ⅰ期与Ⅱ期以上组间比较均有显著性差异（Ｐ＜０．０５，Ｐ＜０．０５，Ｐ＜０．０５）。血清中ＩＬ４水平在内异症Ⅱ期以上组与对照组相比有显著性差异（Ｐ＜０．０５）。ＩＦＮγ在腹腔液中内异症各期组与对照组比较均有显著性差异（Ｐ＜０．０５，Ｐ＜０．０１）。结论 子宫内膜异位症腹腔液中ＩＬ４、ＩＦＮγ变化较血清中明显。随着内异症期别的增加，腹腔液ＩＬ４、ＩＦＮγ均有上升的趋势，尤以ＩＬ４升高更为明显。子宫内膜异位症血清中抗子宫内膜抗体的变化较腹腔液中明显。
Objective To investigate the immunological changes in patients with endometriosis. Methods 18 cases of normal reproductive age women and 34 cases of endometriosis were detected in serum and peritoneal fluid anti-endometrial antibodies, IL 4, IFN γ levels. Results Serum endometriosis group compared with the control group, anti-endometrial antibody positive rate was significantly different (P <0.005); IL 4 levels in the peritoneal fluid in the endometriosis stages compared with the control group and the difference There was significant difference between the first stage and the second stage of disease (P <0.05, P <0.05, P <0.05). Serum levels of IL4 in endometriosis Ⅱ more than the control group, there was a significant difference (P <0.05). IFNγγ in peritoneal fluid in endometriosis stages compared with the control group were significantly different (P <0.05, P <0.01). Conclusion The changes of IL4 and IFNγ in peritoneal fluid of endometriosis are more obvious than those in serum. With the increase of other endometriosis, peritoneal fluid IL 4, IFN γ have an upward trend, especially in IL 4 increased more pronounced. Endometriosis serum anti-endometrial antibody changes than the peritoneal fluid significantly.