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目的观察甲型H1N1流感患者的各脏器病理改变和并发症,为甲型H1N1流感早期防治提供依据。方法对1例确诊甲型H1N1流感死亡的患者病例资料进行分析,进一步尸体解剖检验进行病理学观察。结果患者有扁桃体炎、肺部感染、严重肺出血、肺水肿的病理改变;脑水肿严重、小脑扁桃体疝形成并有轻度脑炎的改变;肝脏有轻度肝炎改变,胃肠道黏膜观察到少许炎细胞浸润。结论甲型H1N1流感重症患者的早期治疗中,除抗病毒治疗,儿童或青少年患者,还应该重视肺部感染、脑炎、脑水肿的早期诊断和治疗。
Objective To observe the pathological changes and complications of various organs in patients with swine influenza A (H1N1) and provide evidence for the early prevention and treatment of influenza A (H1N1). Methods A case of a confirmed case of death from Influenza A (H1N1) was analyzed and further autopsy was performed to observe the pathological changes. Results Patients had tonsillitis, pulmonary infection, severe pulmonary hemorrhage, pathological changes of pulmonary edema; severe hydrocephalus, cerebellar tonsillar hernia with mild encephalitis; mild hepatic changes in liver and mucosa in gastrointestinal tract Little inflammatory cell infiltration. Conclusion In the early treatment of severe patients with influenza A (H1N1), other than antiviral therapy, children or adolescents, early diagnosis and treatment of pulmonary infection, encephalitis and cerebral edema should be emphasized.