论文部分内容阅读
目的:探讨自然周期和激素替代周期这2种内膜准备方案,对有异位妊娠史患者冷冻胚胎移植周期妊娠结局的影响。方法:回顾性分析行体外受精/卵细胞质内单精子显微注射及冷冻胚胎移植且有异位妊娠史的914例患者,并通过倾向性得分匹配的方法对采用自然周期进行内膜准备的患者(428例)和采用激素替代周期进行内膜准备的患者(486例)进行匹配,最终获得匹配周期379对,分为自然周期组和激素替代组,比较2组的妊娠结局。结果:自然周期组与激素替代组在年龄、体质量指数、先前足月产数、输卵管手术史、原发或继发不孕、诊断、移植日内膜厚度、移植胚胎数、移植胚胎阶段和治疗年份等基本特征上的差异均无统计学意义(P>0.05)。妊娠结局方面,2组患者的异位妊娠发生率并无统计学差异(5.2%比7.5%,P>0.05),而2组间的生化妊娠率、临床妊娠率、分娩率、流产率和多胎率等指标差异也均无统计学意义(P>0.05)。结论:在冷冻胚胎移植周期中,对有异位妊娠史的患者采用自然周期或激素替代周期进行内膜准备,患者异位妊娠的复发风险相似,并可获得相似的妊娠结局。
OBJECTIVE: To investigate the effects of natural endometrial and hormone replacement cycles on endometrial outcome of frozen embryo transfer in patients with ectopic pregnancy. Methods: A total of 914 patients with in vitro fertilization / intracytoplasmic sperm injection and frozen embryo transfer and ectopic pregnancy were retrospectively analyzed. Patients who underwent endometrial preparation by natural cycle were scored by propensity score matching (428 cases) and endometrial preparation (486 cases) with hormone replacement cycle were matched. Finally, 379 matching cycles were obtained, which were divided into natural cycle group and hormone replacement group, and the pregnancy outcomes of the two groups were compared. Results: There were no significant differences in age, body mass index, previous term births, tubal surgery history, primary or secondary infertility, diagnosis, endometrial thickness at transplantation, number of embryos transferred, embryonic stage and There were no significant differences in the basic characteristics such as treatment years (P> 0.05). In terms of pregnancy outcomes, there was no significant difference in ectopic pregnancy between the two groups (5.2% vs 7.5%, P> 0.05), but the rates of biochemical pregnancy, clinical pregnancy, delivery, abortion and multiple births Rate and other indicators were also no significant difference (P> 0.05). CONCLUSIONS: In a frozen embryo transfer cycle, endometrial preparation is performed using a natural or hormone replacement cycle in patients with a history of ectopic pregnancies, with similar risk of recurrent ectopic pregnancy and similar pregnancy outcomes.