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目的研究CD26水平的变化与大肠癌患者的关系。方法应用ELISA法测定120例大肠癌患者手术前后、60例正常对照组血清CD26的水平。结果大肠癌患者手术前血清CD26水平高于正常对照组(t=5.180,P<0.05),术后1个月血清CD26水平较术前降低(t=12.116,P<0.05)。结论血清CD26可作为大肠癌的分子标志物。大肠癌患者血清CD26水平的变化有助于评估病情和评价疗效。
Objective To study the relationship between the changes of CD26 and the patients with colorectal cancer. Methods The levels of serum CD26 in 60 patients with colorectal cancer before and after operation were measured by ELISA. Results The level of serum CD26 in patients with colorectal cancer before operation was significantly higher than that in controls (t = 5.180, P <0.05). The level of CD26 in patients with colorectal cancer one month later was lower than that before operation (t = 12.116, P <0.05). Conclusion Serum CD26 can be used as a molecular marker of colorectal cancer. The change of serum CD26 level in patients with colorectal cancer is helpful to evaluate the condition and evaluate the curative effect.