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[目的]探讨对阿莫西林和克拉霉素耐药的幽门螺杆菌感染患者的治疗手段,以寻找一种有效的治疗方法。[方法]回顾性分析我院100例幽门螺杆菌感染者的不同治疗方案的治疗结果。入选患者分别接受(A组)质子泵抑制剂(咯赛克20mg,1次/d)+左氧氟沙星胶囊(0.2,3次/d)+呋喃唑酮(0.1,3次/d)和(B组)质子泵抑制剂(咯赛克20mg,1次/d)+甲硝唑(0.2,3次/d)+庆大霉素针(8万U,3次/d,po)治疗2W,1月后复查快速尿素酶试验。[结果]A组(左氧氟沙星组)Hp清除率为74%,B组(甲硝唑组)为50%,两组幽门螺杆菌清除率比较差异有统计学意义(P﹤0.05)。[结论]质子泵抑制剂联合左氧氟沙星胶囊及呋喃唑酮具有杀菌率高、不良反应小等优点,建议上作为对阿莫西林和克拉霉素耐药的幽门螺杆菌感染患者首选用药组合。
[Objective] To explore the treatment of amoxicillin and clarithromycin-resistant patients with Helicobacter pylori infection in order to find an effective treatment. [Methods] A retrospective analysis of our hospital 100 cases of Helicobacter pylori infection treatment of different treatment options. The patients were enrolled in the study. The patients received proton pump inhibitor (A group, 20 mg once daily), levofloxacin capsules (0.2, 3 daily doses), furazolidone (0.1, 3 daily doses) and proton Pump inhibitor (LOSICINE 20 mg once daily) + metronidazole (0.2, 3 d) + gentamycin needle (80000 U, 3 times daily, po) for 2 weeks and after 1 month Review rapid urease test. [Results] The clearance rate of Hp in group A (levofloxacin group) was 74% and that in group B (metronidazole group) was 50%. The clearance rate of Helicobacter pylori between the two groups was statistically significant (P <0.05). [Conclusion] Proton pump inhibitors combined with levofloxacin capsules and furazolidone have the advantages of high bactericidal rate and small adverse reactions. It is suggested that the combination of proton pump inhibitor and clarithromycin should be the first choice of drug combination in patients with helicobacter pylori infection resistant to amoxicillin and clarithromycin.