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目的探讨软脉灵口服液治疗血管性痴呆(VaD)患者的临床疗效及对血管性痴呆患者超氧化物歧化酶(SOD)、血管内皮生长因子(VEGF)、雌二醇(E_2)、睾酮(T)水平的影响。方法将60例VaD患者随机分为软脉灵口服液组(治疗组)及盐酸多奈哌齐治疗组(对照组)。采用单盲给药法,治疗组口服软脉灵口服液,每次1支(10 mL),每日3次,1个月为1疗程,连服3个疗程。对照组口服盐酸多奈哌齐(思博海),每次1片(5 mg),每日1次临睡前服用,疗程同治疗组。健康老年体检者(正常对照组)30例。检测SOD、VEGF、E_2、T。并观察各组患者治疗前后简易精神状态量表(MMSE)和日常生活量表(ADL)、中医症状积分等的变化。结果软脉灵口服液能显著提高VaD患者血浆SOD、VEGF水平(P<0.05),提高女VaD患者E_2值、男VaD患者T值及降低男VaD患者E_2值、E_2/T值(P<0.05或P<0.01),提高MMSE积分,降低ADL积分,改善临床症状。结论软脉灵口服液可有效防治血管性痴呆。
Objective To investigate the clinical efficacy of Ruanmailing Oral Liquid in the treatment of vascular dementia (VaD) and its effect on patients with vascular dementia: superoxide dismutase (SOD), vascular endothelial growth factor (VEGF), estradiol (E_2), testosterone ( T) level of influence. Methods Sixty patients with VaD were randomly divided into Ruanmailing Oral Liquid group (treatment group) and Donepezil hydrochloride treatment group (control group). Single-blind administration was used. The treatment group was given oral administration of Ruanmailing Oral Liquid, one (10 mL) each time, 3 times a day, 1 month as a course of treatment, and 3 consecutive courses of treatment. The control group was treated with donepezil hydrochloride (Siebohai) one tablet at a time (5 mg) once a day before going to sleep. The course of treatment was the same as the treatment group. Healthy elderly physical examination (normal control group) 30 cases. Detection of SOD, VEGF, E_2, T. Observe the change of MMSE, ADL, TCM symptom score before and after treatment in each group of patients. Results: Ruanmailing Oral Liquid could significantly increase the levels of plasma SOD and VEGF in VaD patients (P<0.05), increase the E2 value of female VaD patients, increase the T value of male VaD patients, and reduce the E2 value and E_2/T value of male VaD patients (P<0.05). Or P<0.01), increase MMSE scores, reduce ADL scores, and improve clinical symptoms. Conclusion Ruanmailing oral liquid can effectively prevent vascular dementia.