为评价四乙酰基六氮杂异伍兹烷(TAIW)对孕鼠的母体毒性及引起胎鼠畸形的可能性,将88只成年SD大鼠按交配时间随机分为4组,3个染毒组染毒剂量分别为111mg/kg、333 mg/kg和1000 mg/kg,对照组给予3%淀粉溶液。结果显示,TAIW对母体动物体重及胎鼠生长发育均无影响,阴性对照组和3个剂量组均不引起胎鼠产生外观、骨骼和内脏畸形。提示TAIW在本实验剂量下不会产生母体毒性和致畸危害。 To evaluate the maternal toxicity of tetraacetylhexaazaisowurtzitane (TAIW) to pregnant rats and the possibility of fetal malformations, 88 adult SD rats were randomly divided into 4 groups according to the mating time, and 3 exposure groups The doses were 111 mg / kg, 333 mg / kg and 1000 mg / kg, respectively. The control group was given 3% starch solution. The results showed that TAIW had no effect on body weight and fetal rat growth and development, and negative control group and three dose groups did not cause appearance, skeletal and visceral malformations. Tip TAIW in the experimental dose does not produce maternal toxicity and teratogenicity.