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癌症已成为世界人口的第一死因。绝大多数癌症患者均死于肿瘤转移。传统的临床治疗试验推测癌症是一个系统性疾病,因此能够抑制肿瘤生长的药物也能抑制肿瘤转移。有许多研究者对药物治疗转移有怀疑,原因在于这些药物的作用均为细胞抑制的,而非细胞毒性的。本文通过分析调控肿瘤转移的分子通路,阐述一些针对转移的有效的新的药物靶点及治疗进展,并重点讨论一些新的细胞毒性类靶向药物的治疗进展。
Cancer has become the number one cause of death in the world’s population. Most cancer patients die of tumor metastasis. Traditional clinical trials speculate that cancer is a systemic disease, so drugs that inhibit tumor growth also inhibit tumor metastasis. Many investigators have doubts about drug delivery because the drugs are cytostatic rather than cytotoxic. In this paper, we analyze some molecular pathways that regulate tumor metastasis, and explain some new and effective drug targets for metastasis and the progress of treatment, and focus on the treatment progress of some new cytotoxic drugs.