1928年Pelger 首先发现一例患者的中性粒细胞核分叶减少,大部分为杆状核及二叶。1932年Huёt 指出这种现象有家族性遗传。嗣后世界各地相继有报道,遂命名为Pelger-Huёt-粒细胞异常。本病在国外报道发病率为千分之一到万分之一,国内自1959 In 1928 Pelger first found a patient with reduced neutrophil nuclear lobulation, most of the rod-shaped nucleus and two leaves. In 1932 Huёt pointed out that this phenomenon has a familial inheritance. Subsequently all over the world have been reported, then named Pelger-Huёt-granulocyte abnormalities. The incidence of this disease in foreign countries reported one thousandth to one ten thousandth, the domestic since 1959