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引言形态学上可识别的最幼稚的血液细胞,在粒细胞系为原始粒细胞,在红细胞系为原始红细胞。这些细胞成熟变成各种血细胞后,不久则将死亡。为使个体的血细胞不致断绝,需要能复制与本身机能相同的、具分化能力的母细胞,即造血干细胞。 Till等于1961年借脾集落法首先证实具此性质的多能干细胞(CFU-S)之存在。嗣后发现了在体外能形成集落的粒细胞(中性粒细胞)、巨噬细胞的前身细胞(CFU-C或CFC),并建立了定量法。现已知道,CFU-C是从CFU-S稍微分化而向中性粒细胞、巨噬细胞转变的定向干细胞。过去十多年间,关于造血干细胞的研究有惊人的发展,现已成为国内外血液学会议上最
Introduction Morphologically recognized as the most naïve blood cells in the granulocyte line is the original granulocyte in the erythroid line is the original erythrocyte. When these cells mature into a variety of blood cells, they will soon die. In order for the individual’s blood cells not to be cut off, they need to be able to replicate the same differentiating mother cells, that is, hematopoietic stem cells, which function as their own. Till was equal to the presence of pluripotent stem cells (CFU-S) of this nature first confirmed by spleen colonization in 1961. Subsequently, granulocytes (neutrophils) capable of forming colonies in vitro, precursor cells of macrophages (CFU-C or CFC) were found, and a quantitative method was established. It is now known that CFU-C is a committed stem cell that is slightly differentiated from CFU-S to neutrophils and macrophages. Over the past ten years, the research on hematopoietic stem cells has astonishing development, has now become the most important hematology conference at home and abroad