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美国国立癌症研究所肿瘤治疗室(DCT)自1975年建立新的筛选系统后,筛选了大量新的合成化合物和天然产物。本文报道用新的瘤谱试验过的四类药物的数据:(1)临床有效的抗癌药物;(2)新药以及过去临床试验不足但因对新模型有活性而重新临床试验的药物;(3)初期临床试验的药物;(4)发展中的化合物。方法学图1是新筛选系统的图解。采用新系统
The National Cancer Institute Cancer Center (DCT) has screened a number of new synthetic and natural products since the establishment of a new screening system in 1975. This article reports data on four classes of drugs that have been tested with new tumor profiles: (1) clinically effective anti-cancer drugs; (2) new drugs and drugs that have undergone past clinical trials but have re-clinical trials because of activity in the new model; 3) drugs for initial clinical trials; and (4) developing compounds. Methodology Figure 1 is a diagram of a new screening system. Adopt new system