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目的利用超声白蛋白微泡造影剂的“声孔效应”及靶向性,提高前列腺内的药物浓度。方法1周岁SD雄性大鼠40只,分为正常对照组、模型对照组、模型微泡组、舍尼通组和舍尼通微泡组。建模完成后分别处理和治疗。30d后,取前列腺,检测各组前列腺重量,观察病理学改变,测量前列腺组织IL-1β、IL-6和TNF-a含量改变。结果舍尼通组和舍尼通加微泡组前列腺湿重较模型对照组明显降低(P<0.05),慢性炎症的病理表现较模型对照组明显好转,舍尼通微泡组更为明显。前列腺组织IL-1β、IL-6和TNF-α测定结果为:舍尼通组和舍尼通微泡组较模型对照组明显减少(P<0.01),和舍尼通组相比,舍尼通微泡组IL-1β、IL-6和TNF-a减少更为明显(P<0.05)。结论利用微泡可有效促进大鼠前列腺局部对药物的吸收,从而对前列腺炎的治疗起明显促进作用。
OBJECTIVE To improve the drug concentration in the prostate using the “sound hole effect” and targeting of ultrasound albumin microbubble contrast medium. Methods Forty SD male rats aged 1 year were divided into normal control group, model control group, model microbubble group, senecton group and senemittent microbubble group. After the completion of the modeling process and treatment. After 30 days, the prostate was taken and the prostate weight of each group was measured. The pathological changes were observed. The contents of IL-1β, IL-6 and TNF-a in the prostate tissue were measured. Results Compared with the model control group, the prostate wet weight in the Senecton group and the Senengardan microbubbles group was significantly lower than that in the model control group (P <0.05). The pathological manifestations of chronic inflammation were significantly better than those in the model control group, and were more pronounced in the Senepin microcirculation group. Prostate tissue IL-1β, IL-6 and TNF-α results as follows: The group of senecton and the group of senengib microbubin significantly reduced compared with the model control group (P <0.01) The decrease of IL-1β, IL-6 and TNF-αin the microvesicle group was more obvious (P <0.05). Conclusion The use of microbubbles can effectively promote the local absorption of drugs in the prostate of prostheses, which can significantly promote the treatment of prostatitis.