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药用真菌作为我国传统中医药体系的重要组成部分,有着悠久的历史。它们能够产生丰富的活性次级代谢产物,具有神经保护、抗肿瘤、降血脂等诸多药效。然而,目前对大部分药用真菌次级代谢产物的化学和生物学研究较少。本课题组主要以抗肿瘤、抗炎、抗菌以及抗病毒等生物活性为指导,选择重要药用真菌进行化学研究,构建我国特色药用真菌代谢产物库。文章主要介绍近4年我们在这方面的研究进展。
Medicinal fungi, as an important part of China’s traditional Chinese medicine system, have a long history. They can produce a wealth of active secondary metabolites, with neuroprotection, anti-tumor, hypolipidemic and many other effects. However, there are currently few chemical and biological studies on most of the secondary metabolites of medicinal fungi. Our research group mainly takes the anti-tumor, anti-inflammatory, antibacterial and antiviral biological activities as the guide, selects the important medicinal fungi for chemical research, and constructs the medicinal fungal metabolic product library in our country. The article mainly introduces our research progress in this area in recent 4 years.