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总结腔内治疗加外照射根治性放疗中晚期胸段食管癌70例的疗效,探寻腔内治疗与外照射较合理剂量搭配。本组病例1年生存率为74.3%,3年25.7%,5年12.5%;同期单纯外照射中晚期食管癌41例的1、3、5年生存率分别为48.8%、17.1%和10.0%。作者认为:1)腔内治疗作为一种辅助治疗手段与外照射结合能提高中晚期食管癌的局部控制率,而对生存率的改善无显著意义。2)适宜的内外照射剂量搭配是提高疗效的关键,对中晚期食管癌较合理搭配剂量为:常规外照射DT60~70Gy/6~7周后改腔内治疗5~10Gy/1~2周。腔内剂量过低不易控制局部病变,剂量过高特别是次量过高易引起食管溃疡甚至穿孔。3)对于胸上段食管癌在进行内外结合治疗的同时,应常规进行双锁骨上区预防性照射。
To summarize the efficacy of intracavitary therapy plus external irradiation radical radiotherapy in 70 patients with advanced thoracic esophageal cancer, to explore the reasonable dose of endoluminal therapy and external irradiation. The one-year survival rate was 74.3% in this group, 25.7% in three years, and 12.5% in five years. The 1-, 3-, and 5-year survival rates of 41 patients with advanced esophageal cancer during the same period were 48. 8%, 17.1% and 10.0%. The authors believe that: 1) Endovascular treatment as an adjunctive treatment combined with external irradiation can improve the local control rate of advanced esophageal cancer, but there is no significant improvement in the survival rate. 2) The appropriate dose of internal and external radiation is the key to improve the efficacy. The more reasonable doses for advanced esophageal cancer are: conventional external irradiation DT60 ~ 70Gy / 6 ~ 7 weeks after the change of endovascular treatment 5 ~ 10Gy / 1 ~ 2 weeks. Intracavitary dose is too low to control local lesions. Excessive doses, especially those that are too high, can cause esophageal ulcers and even perforations. 3) For the treatment of upper thoracic esophageal cancer combined with internal and external treatment, it should be routinely performed with prophylactic radiation in the supraclavicular region.