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已发现在无脊椎动物,促黄体生成素释放激素样物质LHRH可作为外分泌物质,在哺乳类动物的乳汁中亦发现这种现象。提示:LHRH可被外分泌组织生成并分泌;但脊椎动物的性器官上皮是否也能生成LHRH,并分泌入精液,则尚未了解。荷兰Van Minnen等最近发现,LHRH样免疫活性定位于雄性大鼠生殖系统中,附睾,精囊和凝固腺的上皮细胞对于抗LHRH血清的反应很强烈。输精管和前列腺上皮虽亦呈免疫活性,但程度甚小。LHRH可能分泌入雄性生殖道,因为精囊、凝固腺和前列腺腔内的分泌产物亦呈免疫反应。以卵泡刺激素、黄体生成素或β-人绒毛膜促性腺激素抗血清进行实验时,并未发现有阳性免疫染色,在附睾和输精管腔内也来检出LHRH样免疫活性物质。
In invertebrates, LHRH, an LHRH-releasing substance, has been found to be an exocrine substance, also found in mammalian milk. Hint: LHRH can be produced and secreted by exocrine tissue; however, it is not yet known if vertebrate sex organ epithelium can also produce LHRH and secrete into semen. Recently, Holland Van Minnen et al. Found that LHRH-like immunoreactivity was localized in the male rat reproductive system. The epidermal cells of the epididymis, seminal vesicles and coagulated gland responded strongly to anti-LHRH serum. Although the vas deferens and prostate epithelium were also immunocompetent, but to a very small extent. LHRH may be secreted into the male reproductive tract because seminal vesicle, coagulation glands and prostate secretions also showed an immune response. LHRH-like immunoreactive substances were also detected in the epididymis and in the vas deferens lumen when tested with follicle-stimulating hormone, luteinizing hormone or β-human chorionic gonadotropin antiserum.