糖尿病是由多种原因引起的胰岛素分泌不足以及靶细胞对胰岛素敏感性降低,继而引起糖、蛋白质、脂肪及水电解质代谢异常的一种临床综合征。P-糖蛋白作为药物的外排泵,参与了糖尿病及其并发症的发生发展的全过程。糖尿病所引起的体内环境的变化,会导致各组织中P-糖蛋白功能和表达发生改变,而这种改变又会进一步影响药物治疗的药理毒理效应。因此研究糖尿病状态下各组织中P-糖蛋白功能和表达的改变模式及其机制对于糖尿病及其并发症的治疗具有极其重要的临床意义。 Diabetes mellitus is a clinical syndrome caused by a variety of causes of inadequate insulin secretion and reduced sensitivity of target cells to insulin, which in turn causes abnormal metabolism of sugars, proteins, fats and water electrolytes. P-glycoprotein as a drug efflux pump, involved in the development of diabetes and its complications of the entire process. The changes of the in vivo environment caused by diabetes will lead to the changes of the function and expression of P-glycoprotein in various tissues, and this change will further affect the pharmacological and toxicological effects of the drug treatment. Therefore, it is extremely important clinical significance to study the change pattern and mechanism of P-glycoprotein function and expression in various tissues under the condition of diabetes mellitus for the treatment of diabetes mellitus and its complications.