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(一)注射α-MMT(50毫克/公斤)或利血平(1毫克/公斤),30分钟后大白鼠脑内NA 含量即明显下降,2小时到达最低水平,并维持于该水平24小时以上。两个药物都使大白鼠操作式条件反射受到抑制,但α-MMT 组条件反射恢复比 NA 含量的回升早得多。(二)单胺氧化酶抑制剂苯乙肼不能完全阻断利血平降低 NA 含量的作用,仅使之推迟,但可完全阻断α-MMT 的作用。苯乙肼处理的大白鼠,注α-MMT 后再给利血平,脑内 NA 含量仍下降,因此α-MMT 影响 NA 含量的机制和利血平是不同的。α-MMT 的翻转性兴奋较利血平更明显而恒定。
(A) Injection of α-MMT (50 mg / kg) or reserpine (1 mg / kg), NA content in the brain of rats decreased significantly after 30 minutes, reached the lowest level in 2 hours and maintained at that level for 24 hours the above. Both drugs inhibited ophthalmic conditioned reflex in rats, but the conditioned reflex recovery in the α-MMT group was much earlier than that in the NA content. (B) monoamine oxidase inhibitor phenelzine can not completely block the role of reserpine lowering NA content, only delayed, but can completely block the role of α-MMT. In the rats treated with phenelzine, the content of NA in the brain decreased after the injection of α-MMT and reserpine. Therefore, the mechanism by which α-MMT affects the content of NA is different from that of reserpine. α-MMT overturning excitement more stable than reserpine more constant.