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目的探讨晚期胃癌患者应用中药辅助胃癌根治加化疗治疗的临床疗效以及对患者生活质量的影响。方法选取2014年1月至2015年6月收入医院治疗的60例晚期胃癌患者为研究对象,根据治疗方法的不同分为对照组与观察组,每组30例。两组均采取D2根治性切除术联合XELOX辅助化疗,观察组在此基础上增加扶正清解方治疗,采用Karnofsky功能状态评分评价治疗后症状改善情况,比较两组毒副反应发生情况、免疫功能与生活质量。结果观察组治疗效果明显优于对照组;观察组QOL评分高于对照组;观察组出现骨髓抑制、肝功能损害与肾功能损害的例数明显少于对照组;两组治疗后CD3~+与CD4~+值均较治疗前提高,且观察组治疗后CD3~+与CD4~+值高于对照组,上述差异均具有统计学意义(P<0.05)。结论在胃癌根治术联合化疗的基础上,增加扶正清解方辅助治疗不但能够缓解患者的临床症状,提高患者机体免疫力,而且还可降低毒副反应发生率,可提高患者生活质量,安全性较高,值得临床推广并应用。
Objective To investigate the clinical efficacy of traditional Chinese medicine in the treatment of patients with advanced gastric cancer by radical and chemotherapeutic treatment of gastric cancer and the impact on the quality of life of patients. Methods Sixty patients with advanced gastric cancer admitted to the hospital from January 2014 to June 2015 were selected as study subjects and divided into control group and observation group with 30 cases in each group according to different treatment methods. D2 radical resection combined with XELOX adjuvant chemotherapy was used in both groups. In the observation group, Fuzheng Qinggan Decoction was added to the observation group, symptom improvement after treatment was evaluated by Karnofsky functional state score, and the incidence of side effects, immune function And quality of life. Results The observation group had better curative effect than the control group. The QOL score of the observation group was higher than that of the control group. The number of cases with bone marrow suppression, liver function damage and renal dysfunction in the observation group was obviously less than that in the control group. CD3 ~ + CD4 ~ + values were higher than those before treatment, and the levels of CD3 ~ + and CD4 ~ + in the observation group were significantly higher than those in the control group (P <0.05). Conclusions Based on radical gastrectomy combined with chemotherapy, the adjuvant treatment of Fuzheng Qinghai Decoction can not only relieve the clinical symptoms of patients and improve the immunity of patients, but also reduce the incidence of toxic and side effects and improve the quality of life and safety of patients Higher, it is worth to clinical promotion and application.