有机磷农业杀虫药已广泛应用于农业植物保护。它是一种有机磷酸脂类化合物,大多数对人畜均有毒性,有些是剧毒类。在生产、使用过程中经呼吸道吸入或经皮肤接触吸收致毒,严重者可导致死亡。在生活中可因自服、误服或污染食物而致中毒者也相当常见。有机磷中毒后经急救处理而获缓解,但抢救不及时或重度的中毒常因肺水肿、脑水肿及呼吸循环衰竭而死亡。因此及时又积极诊治中毒后的肺水肿是至关重要的。有机磷进入体内与胆硷脂酶(Cholinesterase,ChE),结合形成磷酰化ChE,这种结合是比较稳定,使ChE失去分解乙酰胆硷(Acetylcholine,Ach)的活力,导致Ach在体内大量 Phosphorus pesticides have been widely used in agricultural plant protection. It is an organophospholipid compound, most of which are toxic to humans and animals, some of which are highly virulent. In the production and use of the respiratory tract inhalation or absorption by the skin poisoning, severe cases can lead to death. It is quite common in life to be poisoned by self-serving, mistreatment or contamination of food. After organophosphate poisoning was relieved by emergency treatment, but not timely or severe rescue poisoning often due to pulmonary edema, cerebral edema and respiratory failure and death. Therefore, timely and active diagnosis and treatment of pulmonary edema after poisoning is crucial. Organic phosphorus into the body with the cholinesterase (ChE), combined to form phosphorylated ChE, this combination is relatively stable, ChE loss of decomposition of acetylcholine (Acetylcholine, Ach) activity, resulting in a large number of Ach in vivo