1967年世界卫生组织口腔癌前状态调查委员会提出:口腔粘膜上出现不能被擦掉的白色斑块,在临床和组织病理学上又不能列入其它疾病者,谓之白斑,是口腔科常见病。60年代以来,各国学者进行了大量的观察和研究工作,但进展缓慢。1963年戴氏报道本病及其防治措施后,我国学者曾做了流行病学调查,基础和临床的研究工作。鉴于缺乏 1967 World Health Organization Oral Precancemic Investigation Committee proposed: the oral mucosa can not be erased on the white plaque, clinical and histopathological can not be included in other diseases, that the white spot, is a common dentistry . Since the 1960s, scholars from various countries have conducted a great deal of observation and research work, but the progress has been slow. 1963 Dai reported the disease and its prevention and treatment measures, our scholars have done epidemiological investigations, basic and clinical research. Given the lack of