在单因素比较的基础上采用二次旋转正交组合设计法优化了苦瓜皂苷的超声-微波协同提取工艺条件,结果表明:以含水量13%的苦瓜干为原料,超微粉碎成苦瓜粉,在超声-微波协同处理(70℃,50W,20 khz)下,最佳提取工艺条件为乙醇体积分数74.6%、原料粒度74μm,料液比1∶18、提取时间973 s,在此最佳工艺条件下苦瓜皂苷的提取率达2.51%。 On the basis of single factor comparison, orthogonal rotation design method was adopted to optimize the ultrasonic-microwave synergistic extraction technology of bitter gourd saponin. The results showed that the bitter gourd powder with 13% Under ultrasonic-microwave co-treatment (70 ℃, 50W, 20 khz), the optimum extraction conditions were ethanol volume fraction 74.6%, raw material particle size 74μm, solid-liquid ratio 1:18, extraction time 973 s, Under the conditions of bitter gourd saponin extraction rate of 2.51%.