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利福霉素SV,利福霉素B二乙胺及利福平是利福霉素类抗菌素中评价最高的抗结核新药,也是抗菌、抗麻风新药,主要用于肺结核复治。1957年,意大利首先从法国土壤中分离出地中海链丝菌,在培养发酵液中发现利福霉素。后来,又从各国土壤中分离的链丝菌,选出产生菌,在发酵液中获得利福霉素A、B、C、D、E五种新抗菌素,从利福霉素B氧化获得利福霉素O,水解获得利福霉素S,再还原获得利福霉素SV(Rifamy
Rifamycins SV, rifamycin B diethylamine and rifampin are the most highly evaluated antituberculosis drugs in the rifamycin class of antibiotics, as well as antibacterial and anti-leprosy drugs, which are mainly used in the treatment of tuberculosis. In 1957, Italy first isolated Streptomyces mediterranei from French soils and found rifamycin in the culture broth. Later, from the soil in the country separated from Streptomyces, selected strains of bacteria, obtained in the fermentation broth rifamycin A, B, C, D, E five new antibiotics, obtained from rifamycin B oxidation Foxomycin O, obtained rifamycin S by hydrolysis, and then reduced to obtain rifamycin SV (Rifamy