热休克蛋白60主要定位于细胞线粒体内,但人体在正常和应激情况下均可在外周循环中检测到热休克蛋白60及其抗体。热休克蛋白60在扩张型心肌病患者心肌中异位表达明显增加,其血清抗体水平也明显上升,它可能通过促炎症反应、免疫调节、抗凋亡等多种机制参与扩张型心肌病的发生和发展。 Heat shock protein 60 is mainly located in the mitochondria of cells, but the human body can detect the heat shock protein 60 and its antibody in the peripheral circulation under normal and stress conditions. Hyperactive shock protein 60 in patients with dilated cardiomyopathy ectopic expression increased significantly, the level of serum antibodies also increased significantly, it may be involved in dilated cardiomyopathy by a variety of mechanisms such as pro-inflammatory response, immune regulation, anti-apoptosis And development.