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凋亡相关基因如 ICE(IL-1βconverting enzyme),Fas/Apo-1,Fas-L等与细胞毒T细胞(cytotoxic T cell,CTL)效应以及免疫应答的调节包括活化诱导的细胞死亡(Activation inducedcell death,AJCI)等多项免疫功能有关. 为了解凋亡相关蛋白在肿瘤免疫中的作用,对食管癌中ICE,Fas,Fas-L及凋亡细胞进行标记,探讨其在肿瘤免疫中的作用.采用免疫组化LSAB的方法对46例食管癌手术切除标本中促凋亡相关蛋白ICE,FaS,Fas-L蛋白进行标记,并对其中13例进行TdT介导dUTP缺口末端标记(TdT mediated dUTP nick end labeling,
Apoptosis-related genes such as ICE (IL-1β converting enzyme), Fas/Apo-1, Fas-L, etc. and cytotoxic T cell (CTL) effect and immune response regulation include activation-induced cell death (Activation induced cell Death, AJCI, etc. are involved in many immune functions. To understand the role of apoptosis-related proteins in tumor immunity, markers of ICE, Fas, Fas-L and apoptotic cells in esophageal cancer are labeled to explore their role in tumor immunity. The immunohistochemical method of LSAB was used to label the pro-apoptotic proteins ICE, FaS and Fas-L in 46 specimens of esophageal carcinoma, and TdT-mediated dUTP mediated dUTP was performed in 13 of them. Nick end labeling,