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目的探讨系膜增生性肾小球肾炎（ＭｓＰＧＮ）患者尿Ⅳ型胶原（Ｃ－Ⅳ）、层粘连蛋白（ＬＮ）的变化及其与病理改变 的关系和作用。方法采用放射免疫分析法对４２例肾功能正常的轻、中度系膜增生及合并肾小管病变患者及７８例正常人 尿 Ｃ－Ⅳ、ＬＮ水平进行检测。结果 ＭｓＰＧＮ患者尿 Ｃ－Ⅳ、ＬＮ水平［（４２．８７±５．１２） ｕ ｇ／Ｌ，（９２．３４±２９．１８） ｎｇ／Ｌ］明显高于正常对 照组［（１０．８３±１．６５） ｕｇ／Ｌ， （１．４５±５．２）ｎｇ／Ｌ］（Ｐ＜０．００１）；随着系膜增生程度的增加尿Ｃ－Ⅳ、ＬＮ水平递增，在伴有肾小管病 变患者尿Ｃ－Ⅳ、ＬＮ水平增高最为明显。结论ＭｓＰＧＮ存在胶原代谢的异常，尿Ｃ－Ⅳ、ＬＮ水平随肾脏病理损害的严重程度 而增高，尿Ｃ－Ⅳ、ＬＮ可作为评估ＭＳＰＧＮ肾功能的早期指标。
Objective To investigate the changes of urinary type Ⅳ collagen and laminin (LN) in patients with mesangial proliferative glomerulonephritis (MsPGN) and its relationship with pathological changes. Methods Radioimmunoassay was used to detect the levels of urinary C-Ⅳ and LN in 42 patients with mild and moderate mesangial hyperplasia and tubulointerstitial disease and 78 normal controls. Results The urinary levels of C-Ⅳ and LN in patients with MsPGN were significantly higher than those in the normal controls [(42.87 ± 5.12) ug / L, (92.34 ± 29.18) ng / L [(10.83 ± 1.65) ug / L, (1.45 ± 5.2) ng / L] (P <0.001). Urine C-Ⅳ and LN levels increased with the increase of mesangial proliferation. Tubal lesions in patients with urine C-Ⅳ, LN increased the most obvious. Conclusions MsPGN has the abnormal collagen metabolism. Urinary C-IV and LN levels increase with the severity of renal pathological changes. Urine C-IV and LN can be used as early indicators to evaluate the renal function of MSPGN.