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昼夜节律钟与细胞周期是两个重要的生物过程。昼夜节律钟是机体的分子时间调节系统;而细胞分裂周期调节细胞的发展和细胞更新。一些细胞周期相关基因的表达在节律钟的调控下被其复合物所调节。其中包括NPAS2/CLOCK和BMAL1/CLOCK二聚体复合物。这些复合物调节PER1/PER2的转录。近期的研究表明,节律基因PER1和PER2在DNA损伤反应通路中表现明显,诱导PER1和PER2在癌细胞中可以抑制细胞增殖和提高调亡率。另外在人类的许多癌症中存在PER1和PER2蛋白的丢失和失调。最新研究证实PER1和PER2参与了ATM-chk1/chk2的DNA损伤反应通路,并且预示作为一肿瘤抑制因子起作用。现将PER1和PER2在肿瘤的研究进展综述如下。
Circadian clock and the cell cycle are two important biological processes. Circadian clock is the body’s molecular time-regulating system; and cell division cycle regulates cell development and cell renewal. The expression of some cell cycle related genes is regulated by their complexes under the regulation of the clock. These include NPAS2 / CLOCK and BMAL1 / CLOCK dimer complexes. These complexes regulate PER1 / PER2 transcription. Recent studies have shown that the PER1 and PER2 rhythmic genes in the DNA damage response pathway obvious performance, induced PER1 and PER2 in cancer cells can inhibit cell proliferation and increase the rate of apoptosis. In addition, the loss and dysregulation of PER1 and PER2 proteins are present in many cancers in humans. Recent studies confirm that PER1 and PER2 are involved in the ATM-chk1 / chk2 DNA damage response pathway and are predicted to function as a tumor suppressor. Now PER1 and PER2 in tumor research progress are summarized below.