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本研究采用直肠灌注MNNG诱发小白鼠大肠癌,结果:诱发率84.62％;实验组小鼠免疫功能降低,T淋巴细胞总数与肠肿瘤厚度呈负相关;血清胆固醇在诱癌过程中并非重要因素;在一定遗传背景下,单纯机械刺激亦可诱发大肠癌;小鼠大肠癌起源方式与人类大肠癌不同,但其组织结构、生物学行为以及部分小鼠存在肿瘤高发倾向等均与人类相似;癌组织间质反应程度与癌浸润深度无一定规律性;HID/AB和PAS/AB染色显示肠癌细胞失分泌。根据实验结果,提出了小鼠大肠癌的病理诊断标准。
In this study, rectal perfusion of MNNG induced colorectal cancer in mice, and the result was that the induction rate was 84.62%. The immune function of the experimental group was decreased, and the total number of T lymphocytes was negatively correlated with the thickness of the intestinal tumor. Serum cholesterol was not an important factor in the process of cancer induction. In a certain genetic background, simple mechanical stimulation can also induce colorectal cancer; the origin of colorectal cancer in mice is different from human colorectal cancer, but its tissue structure, biological behavior, and high incidence of tumor in some mice are similar to humans; There was no regularity in the degree of tissue interstitial reaction and the depth of invasion of cancer; HID/AB and PAS/AB staining showed the secretion of colorectal cancer cells. According to the experimental results, the pathological diagnostic criteria for mouse colorectal cancer were proposed.