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在寻找日本血吸虫病治疗药物的研究中,已发现对羧甲巯基苯睇酸具有显著疗效。氨基酸为生物体的重要组成成份,以氨基酸为载体的治疗药物,往往毒性低,疗效亦高,因此合成带有氨基酸的苯(月弟)酸,以试验对血吸虫病的治疗作用,颇有意义,本文报道对-α-氨基乙酸的苯(月弟)酸及其酯的合成。α-氨基苯乙酸直接硝化,硝基取代在间位上。经乙酰化后再行硝化,便可获得对位硝
In the search for a drug for the treatment of schistosomiasis japonica, it has been found that there is a significant effect on carbamazepin. Amino acids are important components of organisms, amino acid-based therapeutic drugs, often low toxicity, efficacy is also high, so the synthesis of amino acids with benzene (cousin) acid, to test the therapeutic effect of schistosomiasis, of great significance , This paper reports the synthesis of p-α-amino-acetic acid benzene (Yue) acids and their esters. Alpha-aminophenylacetic acid is directly nitrated and nitro is substituted at the meta position. After acetylation and then nitrification, can be obtained on the position of nitrate