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目的：观察８４例口腔粘膜鳞状细胞癌术前诱导化疗后肿瘤缩小的程度。方法：实验室检查（血小板、血色素、白细胞计数和肝、肾功能），消化道反应和术中、术后的相关症状。结果：肿瘤缩小以化疗后第７～１４天最为显著；全血下降从第３天开始，到第１４天停止，第２０天恢复到正常下限水平；肾毒性起自第３天，第１４天左右结束；消化道反应中的食欲下降可一直维持到第１４天以后。通过本组的研究资料表明：诱导化疗后手术时机的选择和疗效、预后及术后机体的恢复有着密切的关系。结合对照组中１２例行姑息化疗患者肿瘤再生长的时间。结论：术前高剂量诱导化疗后手术时机的选择以化疗起始第２１天左右为宜。
Objective: To observe the extent of tumor shrinkage after preoperative induction chemotherapy in 84 cases of oral mucosal squamous cell carcinoma. Methods: Laboratory tests (platelets, hemoglobin, white blood cell count, and liver and kidney function), digestive tract reactions, and intraoperative and postoperative symptoms. RESULTS: Tumor shrinkage was most pronounced on days 7 to 14 after chemotherapy; whole blood decline began on day 3 and stopped on day 14 and returned to normal lower limit on day 20; nephrotoxicity started on day 3 and day 14. Left and right ends; the loss of appetite in the digestive tract reaction can be maintained until after the 14th day. According to the research data of this group, there is a close relationship between the choice of surgical timing after induction chemotherapy and the efficacy, prognosis and postoperative recovery of the body. The time of tumor re-growth in patients with palliative chemotherapy was combined with 12 patients in the control group. Conclusion: The choice of surgical time after high-dose induction chemotherapy before surgery is appropriate for the first 21 days of chemotherapy.