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目的探讨中老年人群非酒精性脂肪肝(NAFLD)合并胆石症(GD)的危险因素。方法符合NAFLD诊断的中老年健康体检者1117例分为单纯性NAFLD(A组,853例)和合并GD(B组,264例)两组;对照组(C组,1934例)为无NAFLD和GD的健康者。检测相关指标,分析NAFLD合并GD的危险因素。结果多因素Logistic回归分析结果表明,女性、年龄≥55岁、高血压、糖尿病和高水平ALT、三酰甘油和尿酸(UA)是NAFLD合并GD发病的高危因素,高水平高密度脂蛋白胆固醇人群NAFLD合并GD发病的风险显著降低(P<0.01)。结论对上述高危人群应采取调整血脂、UA、血糖以及控制高血压等针对性综合措施,预防NAFLD合并GD的发生。
Objective To explore the risk factors of non-alcoholic fatty liver disease (NAFLD) complicated with cholelithiasis (GD) in middle-aged and elderly people. Methods A total of 1117 healthy subjects with NAFLD were divided into two groups: simple NAFLD (group A, 853 cases) and GD (group B, 264 cases); control group (group C, 1934 cases) without NAFLD and GD healthy person. The related indexes were detected to analyze the risk factors of NAFLD combined with GD. Results Multivariate Logistic regression analysis showed that women, age 55 years or older, high blood pressure, diabetes mellitus and high levels of ALT, triglyceride and uric acid (UA) were risk factors for NAFLD with GD, high-density HDL cholesterol The risk of NAFLD with GD was significantly lower (P <0.01). CONCLUSIONS: Targeted and comprehensive measures such as adjusting blood lipids, UA, blood glucose, and controlling hypertension should be taken for the above-mentioned high risk population to prevent the occurrence of NAFLD complicated with GD.