抗瘤酮是存在于人尿中由酞及氨基酸衍生物组成的混合物,Burzynski 于1967年首次分离并证实其抗癌活性。其中 A10为纯化得到的第一个活性成分。实验证明它不仅具有较好的临床效果,而且在肝瘤发生的化学预防方面有一定价值。副作用轻是其最大特点,其作用机理复杂,国内外已对其化学结构与 DNA 作用方式等进行了深入研究。与 DNA 可逆性结合抑制 DNA 的突变可能是药物的主要作用方式。 Anti-tumor ketones are a mixture of guanidine and amino acid derivatives found in human urine. Burzynski first isolated and confirmed its anti-cancer activity in 1967. Among them, A10 is the first active ingredient obtained through purification. Experiments have proved that it not only has good clinical effects, but also has a certain value in the prevention of liver tumors. The side effects of lightness are its greatest characteristics, and its mechanism of action is complex. At home and abroad, the chemical structure and the mode of DNA action have been studied in depth. DNA reversible binding to DNA may be the main mode of action of drugs.