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以PEG提取的血清IgG刺激正常人甲状腺细胞cAMP的生成测定TSAb。GD未治组和复发组TSAb活性与阳性率均显著高于GD 缓解组、单纯甲状腺肿组、对照组;GD 缓解组TSAb 活性与阳性率明显降低,但仍高于单纯甲状腺肿组和对照组;后两组TSAb 活性相似,且TSAb 均为阴性。提示TSAb 与GD 的发生和转归密切相关;本法检测TSAb 具有较高的敏感性和特异性。
Serum IgG extracted with PEG stimulates cAMP production in normal human thyrocytes. The activity and the positive rate of TSAb in GD group and remission group were significantly higher than those in GD remission group, simple goiter group and control group. The activity and the positive rate of TSAb in GD remission group were significantly lower than those in simple goiter group and control group TSAb activity in the latter two groups were similar, and TSAb was negative. It is suggested that TSAb is closely related to the occurrence and prognosis of GD. The detection of TSAb by this method is of high sensitivity and specificity.