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目的:观察凉血活血化瘀法治疗过敏性紫癜(HSP)患儿的临床疗效及对血清白细胞介素(IL-6,IL-8)、肿瘤坏死因子-α(TNF-α)的调节作用。方法:选择HSP患儿60例,随机分为治疗组和对照组各30例,另选20例健康儿童作为健康组。采用ELISA双抗体夹心法测定2组患儿治疗前后及20例健康儿童的IL-6、IL-8、TNF-α的血清水平。结果:总有效率治疗组93.3%,对照组76.6%,2组比较,差异有显著性意义(P<0.05),治疗组疗效优于对照组。2组治疗前血清IL-6、IL-8、TNF-α水平均明显高于健康组,差异有显著性意义(P<0.05)。治疗后治疗组血清IL-6、IL-8、TNF-α水平及对照组血清TNF-α水平与健康组比较,差异无显著性意义(P>0.05);对照组血清IL-6、IL-8水平仍高于健康组,差异有显著性意义(P<0.05)。结论:凉血活血化瘀法治疗过敏性紫癜患儿疗效显著,调节患儿IL-6、IL-8、TNF-α水平可能是其治疗HSP的作用机制之一。
Objective: To observe the clinical effects of cooling blood, activating blood circulation and removing blood stasis method in the treatment of children with Henoch-Schonlein purpura (HSP) and the regulation of serum interleukin (IL-6, IL-8) and tumor necrosis factor-α . Methods: Sixty children with HSP were selected and randomly divided into treatment group (30 cases) and control group (30 cases). Another 20 healthy children were selected as healthy group. Serum levels of IL-6, IL-8 and TNF-α in two groups of children before and after treatment and in 20 healthy children were detected by ELISA double antibody sandwich method. Results: The total effective rate was 93.3% in the treatment group and 76.6% in the control group. There was significant difference between the two groups (P <0.05). The curative effect in the treatment group was better than that in the control group. The levels of serum IL-6, IL-8 and TNF-α in two groups before treatment were significantly higher than those in healthy group (P <0.05). The levels of IL-6, IL-8 and TNF-α in the treatment group and the level of TNF-α in the control group were not significantly different from those in the healthy group (P> 0.05) 8 level is still higher than the healthy group, the difference was significant (P <0.05). Conclusion: The treatment of children with Henoch-Schonlein purpura by the method of cooling blood, activating blood circulation and removing blood stasis has significant curative effect. Regulating the levels of IL-6, IL-8 and TNF-α in children may be one of its mechanisms in the treatment of HSP.