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目的：探讨艾司西酞普兰与西酞普兰治疗抑郁症的临床疗效及安全性。方法将60例抑郁症患者按就诊顺序随机分为艾司西酞普兰组和西酞普兰组，每组30例，分别口服艾司西酞普兰、西酞普兰治疗，观察6周。于治疗前后采用汉密顿抑郁量表评定临床疗效，副反应量表评定不良反应。结果治疗第6周末艾司西酞普兰组总有效率为86.67%，西酞普兰组为83.33%，两组比较差异无显著性(P >0.05)。艾司西酞普兰组治疗第1周末起，西酞普兰组治疗第2周末起汉密顿抑郁症量表总分较治疗前显著降低(P 0.05)。结论艾司西酞普兰治疗抑郁症疗效显著，安全性高，与西酞普兰相当。“,”Objective To explore the efficacy and safety of escitalopram and citalopram in the treatment of depression.Methods Sixty depression patients were divided into two groups of 30 ones each according to visiting order,they took orally escitalopram or citalopram for 6 weeks.Efficacies were assessed with the Hamilton Depression Scale (HAMD)before and after treatment and adverse reactions with the Treatment Emergent Symptom Scale (TESS).Results At the end of the 6 st week treatment total effective rate was respectively 86.67% in escitalopram and 83.33% in citalopram group,which showed no significant group difference (P >0.05).The total score of the HAMD since the end of the 1 th week in escitalopram and since the 2 nd in citalopram group lowered more significantly compared with pretreatment (P 0.05 ).Conclusion Both escitalopram and citalopram have an evident effect and higher safety in the treatment of depression.