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哺乳动物胚胎在植入前接触致畸物是否引起先天性畸形还处于争论中。胚胎在植入后死亡主要由于胚胎或配子接触了具有高细胞毒性的物质损伤染色体而影响胚胎发育导致死亡。由于植入前胚胎所含细胞数很少,故很多生物学检查都不适用,造成了观察其毒性效应的困难。本文研究了不同化学物质对囊胚微核发生的诱发能力以及剂量效应关系。实验用10周龄雌性大鼠,适应性饲养两
Mammalian embryos in contact with teratogenic material before implantation cause congenital malformations are still debating. The death of an embryo after implantation is mainly due to embryonic or gamete exposure to a substance with high cytotoxicity that damages the chromosome and affects embryonic development leading to death. Due to the small number of cells contained in preimplantation embryos, many biological tests are not applicable, resulting in the difficulty of observing their toxic effects. In this paper, the different chemical substances on the induction of blastocyst micronucleus and dose-dependent relationship. Experimental 10-week-old female rats, adaptive feeding two