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目的探讨CT引导下经皮永久性组织间植入125I粒子治疗中晚期肺癌的近期疗效。方法回顾性分析2013年1月~2014年6月于我院就诊的60例中晚期肺癌患者的临床资料,依据治疗方法分为观察组与对照组,每组各30例。对照组给予单纯化疗治疗,观察组采用CT引导下经皮永久性组织间植入125I粒子治疗联合化疗。对比分析两组患者近期疗效与生存质量。结果治疗两个疗程后,观察组总有效率83.33%,明显高于对照组总有效率56.67%,差异具有统计学意义(x2=7.82,P<0.05)。观察组患者生存质量改善率50.00%,明显优于对照组生存质量改善率26.67%,差异具有统计学意义(P<0.05)。结论 CT引导下经皮永久性组织间植入125I粒子联合药物化疗治疗中晚期肺癌,疗效显著,能提高患者生存质量,值得临床推广应用。
Objective To investigate the short-term curative effect of CT guided percutaneous 125I implantation on advanced lung cancer. Methods The clinical data of 60 patients with advanced lung cancer who were treated in our hospital from January 2013 to June 2014 were retrospectively analyzed. According to the treatment, the patients were divided into observation group and control group, with 30 cases in each group. The control group was treated with chemotherapy alone, and the observation group underwent CT-guided permanent percutaneous 125I seed implantation combined with chemotherapy. Comparative analysis of two groups of patients with short-term efficacy and quality of life. Results After two courses of treatment, the total effective rate in the observation group was 83.33%, which was significantly higher than that in the control group (56.67%). The difference was statistically significant (x2 = 7.82, P <0.05). The improvement rate of quality of life in observation group was 50.00%, which was significantly better than that in control group (26.67%), the difference was statistically significant (P <0.05). Conclusion CT-guided permanent interstitial implantation of 125I particles combined with drug chemotherapy in the treatment of advanced lung cancer, significant effect, can improve the quality of life of patients, worthy of clinical application.