免疫系统是机体抵御病原体侵袭,维持内环境相对稳定的必要条件。而淋巴细胞是构成机体免疫系统的主要细胞群体,它包括T细胞、B细胞和NK细胞等多种表型和功能各异的细胞。其中,T、B细胞是参与适应性免疫应答的主体,借助二者特异性的抗原识别受体TCR和BCR,机体几乎可以识别一切可能的生化结构,从而应对任何来犯的病原体。然而,如此丰富的TCR和BCR库中亦存在能与自身组织抗原相结 Immune system is the body to resist the invasion of pathogens, to maintain the relative stability of the necessary conditions for the internal environment. Lymphocytes are the major cell populations that make up the body’s immune system and include many phenotypically and functionally diverse cells such as T cells, B cells, and NK cells. Among them, T and B cells are the main body involved in the adaptive immune response. With their specific antigen recognition receptors TCR and BCR, the body can recognize almost every possible biochemical structure, thus responding to any pathogens. However, there is also an abundance of TCR and BCR libraries that bind to self-organizing antigens