论文部分内容阅读
应用维甲酸所致的骨质疏松症模型，灌胃强骨胶囊４５ｍｇ·ｋｇ－１·ｄ－１、９０ｍｇ·ｋｇ－１·ｄ－１、１８０ｍｇ·ｋｇ－１·ｄ－１三个剂量组２８ｄ。结论：该药各组和阿法Ｄ３组与模型组比较均能明显提高大鼠骨密度（Ｐ＜０．０５）、骨结构力学的最大载荷、最大能量吸收值（Ｐ＜０．０５），骨材料力学的弹性应变、最大应力、弹性模量（Ｐ＜０．０５），其中大剂量组（除弹性模量外）作用更为明显且优于阿法Ｄ３组。说明该药能增加骨组织的承载力，提高骨骼抵抗外力冲击的能力，并对骨的几何形状及内在材料特性有一定的改善作用。另外，该药能升高血Ｃａ、Ｅ２、Ｔ、ＦＳＨ、ＢＡＬＰ、ＡＬＰ（Ｐ＜０．０５），降低ＰＴＨ（Ｐ＜０．０５）水平。总之，强骨胶囊具有增加骨密度，改善骨生物力学指标，具有性激素及促性腺激素样作用，可以提高血钙及血、骨中的碱性磷酸酶，促进骨形成，抑制骨吸收。
The model of osteoporosis induced by retinoic acid was administered with three doses of 45 mg·kg-1·d-1, 90 mg·kg-1·d-1, and 180 mg·kg-1·d-1. 28d. Conclusion: Compared with the model group, each group of the drug and the Alpha-D3 group can obviously increase the bone mineral density (P<0.05), the maximum load of bone structural mechanics, and the maximum energy absorption value (P<0.05). The elastic strain, maximum stress, and elastic modulus of bone material mechanics (P<0.05), of which the high-dose group (except for the elastic modulus) was more pronounced and superior to the Alpha-D3 group. It shows that the drug can increase the bearing capacity of bone tissue, improve the ability of the bone to resist the impact of external forces, and has a certain improvement effect on the geometry of the bone and the inherent material properties. In addition, the drug can increase blood Ca, E2, T, FSH, BALP, ALP (P <0.05), reduce PTH (P <0.05) levels. In short, strong bone capsules have increased bone density, improved bone biomechanics, have sex hormones and gonadotropin-like effects, can increase serum calcium, alkaline phosphatase in bone and bone, promote bone formation, and inhibit bone resorption.