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盐酸普魯卡因与硫酸阿託品注射于小白鼠前肢腕部內側正中线深部时其LD_(50)值显著低于同一药物后肢肌內或背部皮下注射。氰化鉀注射于小白鼠或大白鼠的上述部位其毒性显著低于后肢肌內注射与背部皮下注射。亚硝酸鈉LD_(50)值于小白鼠中未見有上述的差别。实驗論証上述毒性差別主要不是因药物自注射部位吸收差別所致。盐酸普魯卡因不論肌內或腕內侧正中线深部注射都能有效地減低氰化鉀的毒性。大白鼠一側臂神經纵切除后一周,再注射氰化鉀于此側的腕內侧正中线深部,其毒性即显著低于正常动物同部位的給药組,故认为氰化鉀毒性的发生可能与神經机制有关。
The LD50 value of procaine hydrochloride and atropine sulfate injected into the medial midline of the forelimb wrist was significantly lower than that of the same drug. Potassium cyanate injection in mice or rats above the site of its toxicity was significantly lower than the hindlimb intramuscular injection and back subcutaneous injection. Sodium nitrite LD_ (50) values in mice did not see the above differences. Experimental evidence that the toxicity difference is not mainly due to differences in absorption of drugs from the injection site. Procalcline hydrochloride can effectively reduce the toxicity of potassium cyanide, regardless of whether the intramuscular or medial midline deep injection is performed. One week after longitudinal excision of the lateral arm of the rat, potassium cyanide was injected into the midline of the medial wrist at this side, which was significantly lower than that of the normal animals at the same site. Therefore, it was considered that the toxicity of potassium cyanide occurred May be related to neural mechanisms.