采用纤维蛋白铺盖和放射免疫方法研究了米非司酮 (RU486)对培养颗粒细胞及黄体细胞纤溶酶原激活因子 (包括组织型 t PA和尿激酶型 u PA)的作用。结果示 RU486能明显拮抗人绒毛膜促性腺激素 (h CG)促进颗粒细胞 t PA活性及孕酮分泌的作用。RU486和 PGF2α能明显促进黄体细胞 t PA分泌 ,但孕酮产生明显被抑制。用组织学培养的方法 ,结果表明 ,RU486能刺激妊娠子宫内膜 t PA和 u PA分泌。这些结果表明 RU486的抗生育作用部分能通过 PA起到抗排卵、溶黄体及抗早孕的作用 The effects of mifepristone (RU486) on cultured granulosa cells and luteal cell plasminogen activator (including tissue-type t PA and urokinase type u PA) were studied using fibrin blanketting and radioimmunoassay. The results showed that RU486 could obviously antagonize the effect of human chorionic gonadotropin (hCG) on t PA activity and progesterone secretion of granulosa cells. RU486 and PGF2α can significantly promote t PA secretion of luteal cells, but progesterone production was significantly inhibited. Histologically cultured, the results show that, RU486 can stimulate pregnancy endometrial t PA and u PA secretion. These results indicate that part of the antifertility effect of RU486 can act as anti-ovulation, corpus luteum and anti-early pregnancy through PA