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目的 糖链抗原CA_(242)和CA_(50)为近年发现的肿瘤血清学标记物,本工作为探讨CA_(50)、CA_(242)在消化道肿瘤中的诊断意义。方法 应用放免法测定164例消化系统恶性肿瘤患者和69例良性疾病患者血清中CA_(50)、CA_(242)水平。结果 两种肿瘤标记物很少在良性疾病患者中升高,假阳性CA_(50) 7.3%,CA_(242) 24.3%。结论 CA_(50)和CA_(242)在消化系统恶性肿瘤患者中的总敏感性分别为70%和63%,CA_(242)在胰管癌的阳性率均较高(79%),两者在肝癌中的敏感性均较低,但在晚期癌瘤患者阳性率较高。
Objective The carbohydrate antigens CA_(242) and CA_(50) are recently discovered serological markers of tumors. This work was to investigate the diagnostic significance of CA_(50) and CA_(242) in digestive tract tumors. Methods The levels of CA 50 and CA 242 in serum of 164 patients with digestive system cancer and 69 patients with benign disease were determined by radioimmunoassay. Results The two tumor markers were rarely elevated in patients with benign disease, with 7.3% false positive CA_(50) and 24.3% CA_(242). Conclusions The total sensitivity of CA_(50) and CA_(242) in patients with digestive system malignancy were 70% and 63%, respectively. The positive rate of CA_(242) in pancreatic duct carcinoma was higher (79%). The sensitivity in liver cancer is low, but the positive rate in patients with advanced cancer is high.