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目的 观察高渗氯化钠羟乙基淀粉 4 0 (HS4 0 )对院前失血性休克的治疗作用 ,探索新的院前失血性休克容量复苏方法。方法 随“1 2 0”救护车外出 ,连续观察使用HS4 0对 4 4例失血性休克的治疗作用 ,分别测定用药前、用药后 30分钟、2、1 2、2 4小时的休克指数、平均动脉压、尿量 ,并与单用等渗羟乙基淀粉液对照和自身前后对照。结果 给药后平均动脉压和尿量比用药前明显增加 (P <0 .0 1～ 0 .0 5 ) ,30分钟和 2小时时相点显著高于对照组 (P <0 .0 5 ) ,2小时后相差不显著。给药后 ,各时相点休克指数比用药前明显降低 (P <0 .0 1～ 0 .0 5 ) ,并且 30分钟和 2小时时相点显著低于对照组 (P <0 .0 5 ) ,2小时后相差不显著 (P >0 .0 5 )。治疗组平均用药量和平均输入时间均低于对照组。结论 HS4 0对失血性休克的容量复苏有明显的治疗作用 ,并且优于单纯的羟乙基淀粉 ,有一定的临床应用价值
Objective To observe the therapeutic effect of hypertonic sodium chloride hydroxyethyl starch 40 (HS40) on prehospital hemorrhagic shock and to explore a new method of prehospital hemorrhagic shock resuscitation. Methods With the “120” ambulance going out, we continuously observed the therapeutic effect of HS4 0 on 44 hemorrhagic shocks. The shock index before treatment, 30 minutes after treatment, 2,1,224 hours were measured, and the mean Arterial pressure, urine output, and with isotonic hydroxyethyl starch solution control and their own before and after the control. Results After treatment, mean arterial pressure and urine volume were significantly increased (P <0.01 ~ 0.05), and were significantly higher at 30 minutes and 2 hours than those of the control group (P <0.05) , 2 hours after the difference is not significant. After administration, the shock index at each time point was significantly lower than that before treatment (P0.01 ~ 0.05), and the points at 30 minutes and 2 hours were significantly lower than those in the control group (P0.05 ), No significant difference after 2 hours (P> 0.05). The average dosage and the average input time of the treatment group were lower than the control group. Conclusion HS40 has a significant therapeutic effect on the volume recovery of hemorrhagic shock, and is superior to simple hydroxyethyl starch, which has certain clinical value