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目的探讨抗生素降阶梯治疗小儿重症肺炎的临床优势。方法选取行抗生素治疗的重症肺炎患儿共75例,将37例行抗生素降阶梯治疗的患儿纳入观察组,38例行抗生素升阶方案治疗的患儿纳入对照组,比较两组患儿的治疗效果、治疗情况、细胞免疫指标及并发症。结果观察组患儿治疗总有效率高于对照组,差异有统计学意义(P<0.05);观察组患儿抗生素使用时间、感染控制时间、肺部病灶吸收率、总住院时间低于对照组,差异有统计学意义(P<0.05);观察组患儿治疗后CD4+、CD4+/CD8+水平高于对照组,CD8+水平低于对照组,差异有统计学意义(P<0.05);两组患儿不良反应发生率比较,差异未见统计学意义(P>0.05)。结论抗生素降阶梯治疗小儿重症肺炎疗效更佳,抗生素使用时间和患者恢复时间更短,炎症控制效果更好,值得临床推荐。
Objective To investigate the clinical advantages of antibiotic descending ladder in the treatment of pediatric severe pneumonia. Methods A total of 75 children with severe pneumonia treated with antibiotics were enrolled in this study. Thirty-seven children treated with antibiotic descending steps were included in the observation group. Thirty-eight children treated with antibiotic regimen were included in the control group. Therapeutic effect, treatment, cellular immune indicators and complications. Results The total effective rate of observation group was higher than that of control group (P <0.05). The antibiotic use time, infection control time, lung lesion absorption rate and total hospital stay in observation group were lower than those in control group (P <0.05). The levels of CD4 + and CD4 + / CD8 + in the observation group were significantly higher than those in the control group, and the levels of CD8 + in the observation group were lower than those in the control group (P <0.05) The incidence of adverse reactions in children, the difference was not statistically significant (P> 0.05). Conclusion The antibiotic descending ladder is more effective in treating pediatric severe pneumonia. The antibiotic use time and patient recovery time are shorter and the inflammation control effect is better. It is worth recommending clinically.