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目的:研究不同配比交泰丸的抗抑郁作用。方法:雄性昆明小鼠按体重随机分为空白对照组、阳性药对照组(盐酸氟西汀7.5 mg.kg-1)及5种不同配比交泰丸高、低剂量组(黄连-肉桂=10:1,1:10,10:0,0:10,1:1),共计12组。各组小鼠ig给药1 h后采用小鼠悬尾实验(TST)、小鼠强迫游泳实验(FST)研究不同配比的交泰丸的抗抑郁作用。结果:在TST和FST中,与空白对照组比较,各给药组小鼠的不动时间均显著减少,其中以交泰丸中黄连与肉桂配比为10:1和1:10时对小鼠不动时间的影响最为明显,即在TST中,交泰丸黄连与肉桂配比为10:1高、低剂量组时小鼠的不动时间分别为(69.8±18.1)s和(79.2±14.6)s,交泰丸黄连与肉桂配比为1:10高、低剂量组时小鼠的不动时间分别为(69.5±21.7)s和(64.1±26.0)s;在FST中,交泰丸黄连与肉桂配比为10:1高、低剂量组时小鼠的不动时间分别为(83.6±29.0)s和(72.9±37.7)s,交泰丸黄连与肉桂配比为1:10高、低剂量组时小鼠的不动时间分别为(92.2±37.8)s和(71.9±35.9)s。交泰丸中黄连与肉桂配比为10:1和1:10组与空白组比较均有显著性差异(P<0.05或P<0.01),并且TST和FST的结果具有一致性(P<0.01)。结论:不同配比的交泰丸均具有抗抑郁的作用,但它们在抗抑郁作用强度上存在差异。
Objective: To study the antidepressant effect of different proportion JiaoTai pill. Methods: Male Kunming mice were randomly divided into blank control group, positive control group (fluoxetine hydrochloride 7.5 mg.kg-1) and five different dosage of Jiao Tai Wan high and low dose group (berberine-cinnamon = 10: 1, 1: 10, 10: 0, 0: 10, 1: 1) for a total of 12 groups. Each group of mice ig administered 1 h after the mouse tail suspension test (TST), mice forced swimming test (FST) with different proportions of Jiatetai Wan antidepressant effect. Results: In TST and FST, compared with the blank control group, the immobility time of mice in each administration group decreased significantly. Among them, when the ratio of Coptis chinensis and Cinnamon in Jiaotai Pill was 10: 1 and 1:10 In TST, the ratio of Coptis chinensis and Cinnamon was 10: 1, and the immobility time of mice in the low dose group were (69.8 ± 18.1) s and (79.2 ± 14.6) s, the ratio of Coptis chinensis and Cinnamon was 1:10 high, the immobility time of the mice in low dose group was (69.5 ± 21.7) s and (64.1 ± 26.0) s respectively; in FST, The ratio of pill to cinnamon was 10: 1, the immobility time of the mice in the low dose group was (83.6 ± 29.0) s and (72.9 ± 37.7) s respectively, the ratio of Coptis chinensis and Cinnamon was 1:10 The immobility time of the mice in high and low dose groups were (92.2 ± 37.8) s and (71.9 ± 35.9) s, respectively. The results showed that there was significant difference (P <0.05 or P <0.01) between the ratio of Coptis chinensis and Cinnamon in Jiaotai Pills by 10: 1 and 1:10, and the consistency of TST and FST ). Conclusion: JiaoTai Pills with different ratios all have the antidepressant effect, but they are different in the intensity of antidepressant effect.