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已知八肽胆囊收缩素（CCK－8）能对抗阿片物质的镇痛作用。本实验首次以大鼠丘脑束旁核中痛兴奋神经元（PEN）、或痛抑制神经元（PIN）放电及辐射热甩尾三者为指标，同时观察了脑室注射CCK－8对抗电针引起丘脑束旁核痛反应神经元放电和甩尾痛阈的影响。结果如下：（1）辐射热照尾可使PEN诱发放电频率增多或PIN诱发放电频率减少的同时发生甩尾反射，表现出疼痛反应。（2）电针双侧“足三里”15分钟，可以抑制PEN和加强PIN的电活动，同时使甩尾反射潜伏期（TFL）延长，呈现出镇痛效应。（3）脑室注射10gCCK－8能对抗电针引起的PEN放电抑制或PIN电活动加强及TFL延长的作用。上述结果证实，CCK－8的抗电针镇痛作用在中枢神经元放电和整体行为水平上是协同一致的。
It is known that octapeptide cholecystokinin (CCK-8) can antagonize the analgesic effect of opioids. This experiment for the first time in rat thalamic paraventricular nucleus pain excited neurons (PEN), or pain inhibition neuron (PIN) discharge and radiant heat flick three as an indicator, while observing the intraventricular injection of CCK-8 against the electroacupuncture induced Effect of thalamic parafascicular nucleus on the pain response and discharge of pain reaction neurons in rats. The results are as follows: (1) Radiation hot tail can make PEN-induced discharge frequency increase or PIN-induced discharge frequency decrease at the same time drift-tail reflex, showing pain response. (2) Electroacupuncture at both sides of “Zusanli” for 15 minutes can inhibit PEN and strengthen the electrical activity of PIN while prolonging the tail flick latency (TFL) and showing analgesic effect. (3) Intraventricular injection of 10 g CCK-8 can counteract the effect of electroacupuncture on the inhibition of PEN discharge or the enhancement of PIN electrical activity and the prolongation of TFL. The above results confirm that the anti-electroacupuncture analgesic effect of CCK-8 is consistent with the central neuron discharge and overall behavioral level.