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目的 探讨降钙素基因相关肽 (CGRP)与脑血管病的发病关系。方法 应用放射免疫分析法检测脑血管病患者血浆CGRP含量。结果 脑梗塞患者急性期血浆 CGRP含量低于恢复期及正常对照组 (P<0 .0 1 ) ,重型患者低于轻型及中型 (P<0 .0 1 ) ,伴原发性高血压病史的急性期患者血浆 CGRP含量低于不伴原发性高血压病史者 (P<0 .0 1 ) ;脑出血患者急性期血浆 CGRP含量高于恢复期及正常对照组 (P<0 .0 1 ) ,重型高于轻型 (P<0 .0 1 )及中型 (P<0 .0 5) ,伴原发性高血压病史者与不伴原发性高血压病史者血浆CGRP含量无差别。结论 CGRP参与了脑血管病的发病过程 ,血浆 CGRP含量检测可以作为脑血管病的临床分型、判断预后的客观指标。
Objective To investigate the relationship between calcitonin gene-related peptide (CGRP) and cerebrovascular disease. Methods Radioimmunoassay was used to detect plasma CGRP in patients with cerebrovascular disease. Results The plasma levels of CGRP in patients with acute cerebral infarction were lower than those in patients with recovery and normal controls (P <0.01), those with severe diseases were lower than those with mild and moderate (P <0.01), with history of essential hypertension The levels of plasma CGRP in patients with acute phase were lower than those without history of hypertension (P <0.01). The levels of plasma CGRP in patients with acute intracerebral hemorrhage were significantly higher than those in patients with convalescence and normal controls (P <0.01) (P <0.01) and medium (P <0.05). There was no difference in plasma CGRP levels between patients with history of essential hypertension and those without history of essential hypertension. Conclusion CGRP is involved in the pathogenesis of cerebrovascular disease. The detection of plasma CGRP content can be used as a clinical classification of cerebrovascular disease and an objective indicator of prognosis.