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肿瘤实验治疗的目的是提高药物的治疗水平,不仅应大力寻找高效低毒的新药,而且还应针对肿瘤化疗失败的原因,寻求相应的对策及其挽救的手段。首先则应剖析化疗受挫诸因素的具体表现。1.肿瘤的因素:癌症发现时多已晚期,癌组织已有大量的坏死出血,形成血栓或癌栓造成血流不畅,倘若播散转移至药物难以到达部位,则逃避药物的杀伤。又因癌细胞动力学特性不一,即使同一肿瘤其细胞的异质性组成、微转移和乏氧细胞的存在,均造成药物
The purpose of tumor experimental treatment is to improve the therapeutic level of drugs. It is not only necessary to vigorously search for new drugs that are highly effective and low in toxicity, but also to search for the corresponding countermeasures and the means for their rescue in response to the failure of cancer chemotherapy. First of all, it should analyze the concrete manifestations of the various factors of chemotherapy frustration. 1. Tumor factors: When the cancer was discovered late, cancer tissue has a lot of necrosis and hemorrhage, blood flow is formed due to thrombosis or cancer emboli. If disseminated to the hard-to-reach location of the drug, escape from drug killing. Because of the different kinetic characteristics of cancer cells, even the heterogeneity of their cells, micrometastases, and the presence of hypoxic cells in the same tumor all cause drugs.